eBOOK | DELIVERY TECHNOLOGIES FOR OLIGONUCLEOTIDE DRUGS

Driving Insight into Structural and Biophysical Properties Through Analytical Programs

The delivery of antisense oligonucleotides (ASOs) to their intended intracellular sites of action remains a significant hurdle that must be overcome in order to realize broader clinical applications for this product class.

In this article, our expert, Ashleigh Wake, UK Business Development Director, discusses a variety of promising delivery technologies which are designed to promote cellular uptake including lipid-based, nano-particle based, and ligand conjugation approaches as well as providing an overview on the methodologies to assess those critical quality attributes required to support development and regulatory submissions.

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